Selected Journal Publications

  • K. Liu and T.H. Wang. " Cylindrical Illumination Confocal Spectroscopy – Rectifying the Limitations of Confocal Single Molecule Spectroscopy through 1-D Beam Shaping ". Biophysical Journal, (Accepted)
  • H.C. Yeh, C.M. Puleo, Y.P. Ho, V.J. Bailey, T.C. Lim, K. Liu and T.H. Wang. " Tunable Blinking Kinetics of Cy5 for Precise DNA Quantification and Single-Nucleotide Difference Detection ". Biophysical Journal, e-pub ahead of print: doi:10.1529/biophysj.107.127530, 2008
  • K. Liu, Y. Zhang and T.H. Wang. " Application of Quantum Dots for Analysis of Biomolecules ". IEEE NANO Magazine (Accepted)
  • C.M. Puleo, H.C. Yeh and T.H. Wang. " Coupling Confocal Fluorescence Detection and Recirculating Microfluidic Control for Single Particle Analysis in Discrete Nanoliter Volumes ". Lab on a Chip, 8:822-825, 2008
  • T.C. Lim, V.J. Bailey, Y.P. Ho and T. H. Wang. " Intercalating dye as an acceptor in quantum dot mediated FRET ". Nanotechnology 19(7):075701, 2008
  • H.H. Chen, Y.P. Ho, X. Jiang, H.Q. Mao, T.H. Wang and K.W. Leong. " Quantitative Comparison of Intracellular Unpacking Kinetics of Polyplexes by a Model Constructed from Quantum Dot-FRET ". Molecular Therapy 16(2):324-332, 2008
  • C.M. Puleo , H.C. Yeh and T.H. Wang. " Applications of MEMS Technologies in Tissue Engineering ". Tissue Engineering 13(12): 2839-2854, 2007
  • S.Y Chao, Y.P. Ho, V. Bailey and T.H. Wang. " Quantification of Low Concentration DNA Using Single Molecule Detection and Velocity Measurement in a Microchannel ". Journal of Fluorescence 17(6):767-774, 2007
  • D.D. Nalayanda, C.M. Puleo, W.B. Fulton, T.H. Wang and F. Abdullah, " Characterization of Pulmonary Cell Growth Parameters in a Continuous Perfusion Microfluidic Environment". Experimental Lung Research 33(6):321-335, 2007
  • H. C. Yeh, C. Puleo, T. C. Lim, Y. P. Ho, P. Giza, R. C. Huang, and T. H. Wang. "A Microfluidic-FCS platform for investigation on the dissociation of Sp1-DNA complex by doxorubicin". Nucleic Acids Research 34(21):e144, 2006
  • Y. P. Ho, H. H. Chen, K. W. Leong, T. H. Wang. "Evaluating the Intracellular Stability and Unpacking of DNA Nanocomplexes by Quantum Dots-FRET".Journal of Controlled Release, 116:83-89, 2006
  • C. M. Puleo, K. Liu, T. H. Wang, "Pushing miRNA quantification to the limits: high-throughput miRNA gene expression analysis using single-molecule detection," Nanomedicine 1(1):123-127, 2006
  • H. C. Yeh, Y. P. Ho, I. M. Shih, T. H. Wang, " Homogeneous point mutation detection by quantum dot-mediated two-color fluorescence coincidence analysis," Nucleic Acids Research 34(5):e35, 2006
  • C. Y. Zhang, H. C. Yeh, M. Kuroki, T. H. Wang, " Single-Quantum-Dot-Based DNA Nanosensor," Nature Materials 4(11):826-831, 2005
  • Y. P. Ho, M. C. Kung, S. Yang, T. H. Wang, " Multiplexed Hybridization Detection with Multicolor Colocalization of Quantum Dot Nanoprobes," Nano Letters 5(9): 1693-1697, 2005
  • H. C. Yeh, S. Y. Chao, Y. P. Ho, T. H. Wang," Single-Molecule Detection and Probe Strategies for Rapid and Ultrasensitive Genomic Detection," Current Pharmaceutical Biotechnology 6(6):453-461, 2005
  • T. H. Wang, Y. H. Peng, C. Y. Zhang, P. K. Wong, C. M. Ho, " Single-molecule tracing on a fluidic microchip for quantitative detection of low-abundance nucleic acids," Journal of the American Chemical Society 127 (15): 5354-5359 2005 (Highlighted in Nanozone news in Nature, April 28, 2005)
  • C. Y. Zhang, S. Y. Chao., T. H. Wang, " Comparative quantification of nucleic acids using single-molecule detection and molecular beacons," Analyst 130 (4): 483-488 2005
  • H. C. Yeh, Y. P. Ho, T. H. Wang, " Quantum dot?mediated biosensing assays for specific nucleic acid detection," Nanomedicine: Biol. Med. 1 (2): 115-121 2005
  • P. K. Wong, C. Y. Chen, T. H. Wang, C. M. Ho, " Electrokinetic bioprocessor for concentrating cells and molecules," Analytical Chemistry 76 (23): 6908-6914 2004
  • P. K. Wong, T. H. Wang, J. H. Deval, C. M. Ho, " Electrokinetics in micro devices for biotechnology applications," IEEE-ASME Transactions on mechatronics 9 (2): 366-376 2004

Selected Conference Publications

  • H. H. Chen, Y. P. Ho, T. H. Wang, K. W. Leong, " Intracellular Trafficking of QD-FRET Nanoparticles for Gene Delivery," Biomedical Engineering Society 2005 (accepted)
  • Y. P. Ho, M. C. Kung, T. H. Wang, " Separation-free Detection of Low-abundant Biomolecules with Two-Color Colocalization of Quantum Dot Probes," Ninth International Conference on Miniaturized Chemical and Biochemical Analysis Systems (MicroTAS 2005) 2005 (accepted)
  • H. C. Yeh, Y. P. Ho, T. H. Wang, " Quantum Dot-Mediated Separation-Free Assay for Single Nucleotide Polymorphism (SNP) Detection," NSTI- Bio-Nanotechnology Conference and Trade Show 2005
  • H. C. Yeh, E. Simone, C. Y. Zhang, T. H. Wang, " Single Bio-molecule Detection with Quantum Dots in a Microchannel," 17th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2004) 371-374 2004
  • S. Y. Chao, C. Y. Zhang, T. H. Wang, " Measurement of in-situ Flow Velocity Using Single-Molecule Detection for the Application of Biomolecule Quantification," 2004 Solid-State Sensor, Actuator, and Microsystems Workshop (Hilton Head 2004) 176-179 2004
  • T. H. Wang, C. M. Ho, " Nano/micro Technologies for Single Molecule Manipulation and Detection," 2003 IEEE international Conference on Robotics and Control 2003
  • P. K. Wong, C.Y. Chen, T.H. Wang, C.M. Ho, " An AC Electroosmotic Processor for Biomolecules," The 12th International Conference on Solid-state Sensors, Actuators, and Microsystems, Transducers'03 2003
  • T. H. Wang, C. M. Ho, " Nano/Micro Technologies for Single Molecule Manipulation and Detection," IEEE 2004 International Conference on Robotics and Automation 2003
  • T. H. Wang, P. K. Wong, C.M. Ho, " Electrical Molecular Focusing for Laser Induced Fluorescence Based Single DNA Detection," The 15th IEEE International Conference on Micro Electro Mechanical Systems (MEMS2002) 15-18 2002
  • P. K. Wong, T. H. Wang, C. M. Ho, " Formation of Optical Fiber Tip by Surface Tension Controlled Etching," 2002 Solid-State Sensor, Actuator, and Microsystems Workshop (Hilton Head 2002) 2002
  • T. H. Wang, C. M. Ho, " A Zepto Mole DNA Micro Sensor," The 14th IEEE International Conference on Micro Electro Mechanical Systems (MEMS2001) 431-434 2001
  • T. H. Wang, S. Masset, C. M. Ho, " Molecular Beacon Based Biological Detection System," The International Conference on Mathematics and Engineering techniques in Medicine and Biological Sciences (METMBS 00') 2000

Book Chapters

  • T. H. Wang, C. M. Ho, " Nano/Micro Technologies for Detecting a Single DNA Molecule," Frontiers in Biomedical Engineering Kluwer Academic/Plenum Publishers 2003

Patents

  • T. H. Wang, Y. P. Ho, " Fluorescence Self-amplification Facilitated by Molecular Nanoprobes and Micro Concentration Devices for Rapid and Ultrasensitive Biological Detection," 2004 (U.S. provisional patent)
  • T. H. Wang, C. Y. Zhang, " Semiconductor quantum-dot based inorganic/organic hybrid biosensor for homogenous separation-free detection of biomolecules," 2004 (U.S. provisional patent)
  • C. M. Ho, J. Liao, T. H. Wang, " Ultrasensitive Molecule Detection of Urinary Tract Infection," (U.S. Patent Pending, UC Case No. 2001-249)
  • C. M. Ho, J. Miller, J. Huang, T. H. Wang, M. Liu, " Electrochemical Detection of Mismatch in Nucleic Acids (EDEMNA)," (U.S. Patent Pending, UC Case No. 2001-158-1)
  • C. M. Ho, T. H. Wang, " Electronics Integrated With Bio-Reactor/Channel For Detection Or Fabrication Of Bio-Materials," (U.S. Patent Pending, UC Case No. 2000-499 )
  • T. H. Wang, " Method for determining standard cycle time of a stage dynamically," U.S. Patent US5825650 1997