BioSensing and BioMEMS 530/580.672

 

Prof. Tza-Huei (Jeff) Wang
class taught:   Mon and Wed, 11:00-12:20pm, 120 Latrobe
office:    108 Latrobe

office number:   

410-516-7086
email:    thwang@jhu.edu

 

Syllabus  

Prerequisites:

Graduate students in engineering and physical science or senior undergraduate students (with permission from the instructor)

Textbook:

There is no textbook. The lecturing is mainly based on the notes, selected research articles of journals, and sections from the following references. The lecture notes and supplementary materials will be posted on the webpage.

References:

  1. A. Manz and H. Becker, Microsystem Technology in Chemistry and Life Science

  2. B. R. Eggins, Chemical Sensors and Biosensors

  3. T. A. Kovacs, Micromachined Transducers Sourcebook

  4. M. Mardou, Fundamentals of Microfabrication

  5. Oosterbroek and van den Berg, Lab-on-a-chip Miniaturized Systems for (Bio)Chemical Analysis and Synthesis

Grading: Homework 40 %,  Midterm exam 30 %,  Final project (report & presentation) 30 %
Homework: Homework will be due one week after it has been given, except when otherwise advised. Homework must be submitted at the beginning of the class on the day it is due. Late submissions will be penalized 10 % for every day it is late up to one week. After one week, homework will not be accepted.
Midterm: March 26, 2007
Final Presentations: April 25, 2007

      HW1:     Due Feb. 7

      HW2 :   Due Feb. 28

      HW3 :   Due March 21

      HW4 :   Due March 23

      Final Project & Presentation

     

Topics: Lecture notes Reading Material
1.      Introduction to BioMEMS  BioMEMS Introduction Lab-on-a-chip
2.      Scaling Laws  Scaling I  Scaling II Feynman Scaling
3.      Microfabrication Process Microfabrication I Microfabrication II Microfabrication
4.     Polymer-based   microfabrication Polymer-based Fabrication Soft Lithography

Etch Rate

5.      Fluidics Basics  Fluids Microfluidics
6.     Microfluidic control & measurement Microfluidic Control I

Microfluidic Control II

Microfluidics-Ho

Molecular Manipulation

7.      Other Forces and fields at the microscale  Force & Field Electrokinetics-I

Electrokinetics-II

8.      Lab-on-chip System Lab-ob-a-chip
9.      Principles of Biosensing    
10.  Micro/Nano Biosensors
11.  Single-Molecule Detection