BioSensing and BioMEMS 530/580.672

 

Prof. Tza-Huei (Jeff) Wang
class taught:   Tue and Thur, 10:30-11:45 am, Krieger 302
office:    108 Latrobe

office number:   

410-516-7086
email:    thwang@jhu.edu

 

Syllabus

Prerequisites:

 Graduate students in engineering and physical science or senior undergraduate students

Textbook:

 There is no textbook. The lecturing is mainly based on the notes, selected research articles of journals, and sections from the following references. The lecture notes and supplementary materials will be posted on the webpage.

References:

  1. A. Manz and H. Becker, Microsystem Technology in Chemistry and Life Science

  2. B. R. Eggins, Chemical Sensors and Biosensors

  3. T. A. Kovacs, Micromachined Transducers Sourcebook

  4. M. Mardou, Fundamentals of Microfabrication

  5. Oosterbroek and van den Berg, Lab-on-a-chip Miniaturized Systems for (Bio)Chemical Analysis and Synthesis
Grading: Homework 30 %,  Midterm exam 25 %,  Project presentations (15 %), Class activities (10%), Final report 20 %
Homework: Homework will be due one week after it has been given, except when otherwise advised. Homework must be submitted at the beginning of the class on the day it is due. Late submissions will be penalized 10 % for every day it is late up to one week. After one week, homework will not be accepted.
Midterm: Oct. 28, 2008
 Presentations:

      HW1:     Due Sep. 23

      HW2 :    Due Oct. 9

      HW3 :  

      HW4 :  

      HW5 :

      Final Project & Presentation

     

Topics: Lecture notes Reading Material
1.      Introduction to BioMEMS  BioMEMS Introduction Lab-on-a-chip
2.      Scaling Laws  Scaling I  Scaling II Feynman Scaling
3.      Microfabrication Process Microfabrication I  Microfabrication II Microfabrication
4.     Polymer-based   microfabrication Polymer-based Fabrication Soft Lithography

Etch Rate
5.      Fluidics Basics 
6.     Microfluidic control & measurement    
7.      Other Forces and fields at the microscale 
8.      Lab-on-chip System
9.  Project discussions    
10. Principles of Biosensing    
11. Micro/Nano Biosensors
12. Single-Molecule Detection